Yidi Sun

Evolutionary Origins of Molecular Programs Underlying Brain Circuitry

This study reconstructs the evolutionary assembly of a conserved cortical axis across vertebrates using spatial transcriptomics and single-nucleus RNA-seq, revealing conserved molecular programs and convergent evolution in brain circuitry.

Single-cell spatial map of cis-regulatory elements for disease-related genes in the macaque cortex

The paper maps cis-regulatory elements in the macaque cortex using snATAC-seq and links them to disease-related genes and risk SNPs.

scMOBA: A conversational single-cell Multi-Omics Brain Agent across species

scMOBA is a multi-omics brain agent that integrates single-cell and spatial data across species, achieving state-of-the-art cell type classification and improving downstream tasks like aging clock construction and disease prediction.

A Population-scale Single-cell Spatial Transcriptomic Atlas of the Human Cortex

This study creates a single-cell spatial transcriptomic atlas of the human cortex, revealing gene expression patterns, aging effects, and disease associations across layers and species.

Genomic evolution reshapes cell type diversification in the amniote brain

The paper creates a single-cell atlas of amniote brains to study cell type diversification and identifies species-specific gene expression patterns and novel cell subtypes.

A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons

The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.

An ultra-sensitive and easy-to-use multiplexed single-cell proteomic analysis

The paper introduces a single-cell proteomic workflow that achieves high sensitivity and throughput for protein quantification in human cell lines.

High-fidelity base editor with no detectable genome-wide off-target effects

The paper identifies base editor variants with reduced off-target effects on both DNA and RNA.

Base editing generates substantial off-target single nucleotide variants

This study compares off-target single nucleotide variants (SNVs) from CRISPR-Cas9 and base editing (BE3) in mouse embryos using the GOTI method, finding BE3 causes significantly more SNVs.

The Evolutionary Landscape of Pan-Cancer Drives Clinical Aggression

This study identifies four pan-cancer evolutionary patterns linked to clinical aggressivity using Bayesian mutation landscape analysis across 21 cancer types.