Shijie Hao

This study reconstructs the evolutionary assembly of a conserved cortical axis across vertebrates using spatial transcriptomics and single-nucleus RNA-seq, revealing conserved molecular programs and convergent evolution in brain circuitry.

This study creates a single-cell transcriptomic atlas of mouse oocyte development from growth to ovulation using a new platform and integrates transcriptomic and morphological data to identify temporal shifts in gene expression.

The paper introduces CIMA, a multi-omics atlas of human immune cells, identifying regulatory mechanisms and genetic associations across sex, age, and genetic factors.

The paper uses single-cell multiomics to study gene regulatory programs in mouse embryonic skin, identifying cis-regulatory elements and transcription factors involved in development.

Spateo provides a framework for spatiotemporal modeling of single-cell spatial transcriptomics data to study cell-cell interactions and organ development in 3D space.

This study presents three Osteoglossidae genomes to explore ancient teleost evolution, revealing divergence times and genomic changes linked to continental drift and dietary adaptations.