Immune Responses Targeting Homocitrullinated Peptides Drive Rheumatoid Arthritis-like Pathology in HLA-DR4 Transgenic Mice
Gabrielle Buckley, Sheri Saunders, Ewa Cairns, Lillian Barra
This study shows that homocitrulline-specific immune responses induce RA-like pathology in HLA-DR4 transgenic mice, supporting the pathogenic role of anti-homocitrullinated protein autoantibodies in RA.
bioRxiv · Sep 17, 2025 · PreprintImmunology