Pharmacology & ToxicologyCell chemical biologyPeer-reviewed
PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication
Lori A. Emert‐Sedlak, Colin M. Tice, Haibin Shi…·Thomas E. Smithgall
This study develops PROTACs to degrade HIV-1 Nef, restoring CD4 and MHC-I expression and inhibiting HIV-1 replication in T cells and PBMCs.
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