Author

John J. Alvarado

University of PittsburghORCID 0000-0001-6274-5997Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Catherine E. ThomasiD· 1 shared Thomas E. SmithgalliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

2 top collaborators · 1 mutual co-author link

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

Catherine E. ThomasORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

MicrobiologybioRxivPreprintAug 11, 2026

HIV-1 Nef Homodimerization as a Structural Mechanism for Kinase Activation and Small Molecule Inhibitor Action

Catherine E. Thomas, John J. Alvarado, Thomas E. Smithgall

This study shows that HIV-1 Nef homodimerization is critical for kinase activation and that disrupting this interface with small molecules inhibits viral replication and restores immune recognition.

DOI 10.64898/2026.08.10.744017

humanprotein structure

𝕏 PostBluesky