Bioinformatics-based stereochemical elucidation of MM 46115: an unusual antiviral spirotetronate that inhibits clathrin-mediated endocytosis
Afifah Tasnim, Lauren A. M. Murray, Rebecca A. Clayton, Chidiebere Francis Uchechukwu, Jinlian Zhao, Shing C. Liu, Mabilly Cox Holanda de Barros Dias, Ning Liu, Ying Huang, Craig Thompson, Lona M. Alkhalaf, Gregory L. Challis, Nicole C. Robb
This paper identifies and characterizes pellemicin, a spirotetronate with antiviral activity against influenza A and B viruses by inhibiting clathrin-mediated endocytosis.
bioRxiv · Sep 18, 2025 · PreprintMicrobiology