Nicole C. Robb

Molecular and Structural Characterisation of the MERS-Coronavirus Polymerase

This study characterizes the MERS-CoV replication-transcription complex and shows its structural similarity to SARS-CoV-2, with cross-species compatibility highlighting evolutionary conservation and virus-specific adaptations.

Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase

This study characterizes the structure and function of CCHFV RNA-dependent RNA polymerase, revealing its unique features and antiviral susceptibility.

Isothermal Detection of Influenza D using RT-LAMP

The paper develops and validates an RT-LAMP assay for detecting influenza D virus with high specificity and sensitivity, offering a cost-effective alternative to RT-qPCR for field use.

High-throughput Single-Virion DNA-PAINT Reveals Structural Diversity, Cooperativity and Flexibility during Selective Packaging in Influenza

This study uses high-throughput DNA-PAINT to analyze influenza virus genome packaging, revealing cooperative and flexible segment interactions that guide genome assembly.

Bioinformatics-based stereochemical elucidation of MM 46115: an unusual antiviral spirotetronate that inhibits clathrin-mediated endocytosis

This paper identifies and characterizes pellemicin, a spirotetronate with antiviral activity against influenza A and B viruses by inhibiting clathrin-mediated endocytosis.

Mechanistic insights into the activity of SARS-CoV-2 RNA polymerase inhibitors using single-molecule FRET

This study uses smFRET to analyze SARS-CoV-2 RNA polymerase inhibitors, revealing remdesivir's mechanism involves polymerase stalling and chain termination.

Nucleobase Methylation Enhances SARS-CoV-2 Chain Terminator Evasion of Exonuclease Proofreading

This study identifies 5-methyl-3'-dUTP as a nucleoside analogue that effectively terminates RNA chains and resists SARS-CoV-2 exoribonuclease proofreading.