Disrupting cellular memory to overcome drug resistance
Guillaume Harmange, Raúl A. Reyes Hueros, Dylan L. Schaff, Benjamin L. Emert, Michael Saint-Antoine, Laura C. Kim, Zijian Niu, Shivani Nellore, Mitchell E. Fane, Gretchen Marie Alicea, Ashani T. Weeraratna, Marie Celeste Simon, Abhyudai Singh, Sydney M. Shaffer
The paper develops a method to quantify gene expression memory and identify regulators of cell state transitions, showing that modulating PI3K and TGF-β pathways can reduce drug resistance in melanoma.
Nature Communications · Nov 6, 2023Peer-reviewedSystems Biology