Author

Guillaume Harmange

Northeastern UniversityORCID 0000-0002-3157-5355Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

Abhyudai SinghiD· 2 shared Benjamin L. EmertiD· 2 shared Bogdan BudnikiD· 2 shared Dylan L. SchaffiD· 2 shared Nikolai SlavoviD· 2 shared Raúl A. Reyes HuerosiD· 2 shared Sydney M. ShafferiD· 2 shared Ann E. SizemoreiD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

Abhyudai SinghORCID

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Author profile →

4 papers

Recent·Most cited

Disrupting cellular memory to overcome drug resistance

Guillaume Harmange, Raúl A. Reyes Hueros, Dylan L. Schaff, Benjamin L. Emert, Michael Saint-Antoine, Laura C. Kim, Zijian Niu, Shivani Nellore, Mitchell E. Fane, Gretchen Marie Alicea, Ashani T. Weeraratna, Marie Celeste Simon, Abhyudai Singh, Sydney M. Shaffer

The paper develops a method to quantify gene expression memory and identify regulators of cell state transitions, showing that modulating PI3K and TGF-β pathways can reduce drug resistance in melanoma.

Nature Communications · Nov 6, 2023Peer-reviewedSystems Biology

Memory sequencing reveals heritable single cell gene expression programs associated with distinct cellular behaviors

Sydney M. Shaffer, Benjamin L. Emert, Raúl A. Reyes Hueros, Christopher J. Cote, Guillaume Harmange, Dylan L. Schaff, Ann E. Sizemore, Rohit K. Gupte, Eduardo A. Torre, Abhyudai Singh, Danielle S. Bassett, Arjun Raj

The paper introduces MemorySeq, a method to identify gene expression fluctuations persisting across cell divisions, revealing non-genetic, heritable cellular behaviors in cancer cell lines.

Cell · Jul 30, 2020Peer-reviewedSystems Biology

Mass-spectrometry of single mammalian cells quantifies proteome heterogeneity during cell differentiation

Bogdan Budnik, Ezra Levy, Guillaume Harmange, Nikolai Slavov

SCoPE-MS combines acoustic cell lysis with isobaric tandem-mass-tag carrier channels to quantify over a thousand proteins in single mammalian cells, resolving cancer cell types and stem cell differentiation.

Genome biology · Oct 9, 2018Peer-reviewedBioengineering✦ In-depth digest

Automated sample preparation for high-throughput single-cell proteomics

Harrison Specht, Guillaume Harmange, David H. Perlman, Edward Emmott, Zachary Niziolek, Bogdan Budnik, Nikolai Slavov

Minimal ProteOmic sample Preparation (mPOP) eliminates cleanup losses in single-cell mass spectrometry proteomics, enabling automated SCoPE-MS profiling that separates mammalian cells by cell type and cell-division-cycle phase.

bioRxiv · Aug 25, 2018 · PreprintSystems Biology