Dissecting sequence determinants of DNA methylation and in silico perturbation
Fa‐Ming Chen, Qinhao Zhang, Shiwei Zhu, Jinxia Liang, Siyun Zhong, Zehong Zhang, Jianzhong Su, Yangfan Guo, Xiaoying Fan, Yan Zhang, Fulong Yu
This paper introduces MethylAI, a deep learning framework that predicts DNA methylation states from genomic sequence and identifies sequence determinants of methylation through in silico perturbation.
bioRxiv · Nov 20, 2025 · PreprintGenomics