Author

Siyun Zhong

Guangzhou Laboratory

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:database / resource· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:variant effect prediction· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Fulong YuiD· 3 shared Qinhao ZhangiD· 2 shared Zehong ZhangiD· 2 shared Boya JiiD· 1 shared Fa‐Ming CheniD· 1 shared Jianzhong SuiD· 1 shared Jiawen WangiD· 1 shared Jinxia LiangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersBioinformatics

Fulong YuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

CAPTAIN: A multimodal foundation model pretrained on co-assayed single-cell RNA and protein

Boya Ji, Tingting Hu, Jiawen Wang, Mengmeng Liu, Liwen Xu, Qinhao Zhang, Siyun Zhong, Libo Qiao, Yan Zhang, Shaoliang Peng, Fulong Yu

CAPTAIN is a multimodal foundation model trained on single-cell RNA and protein data, improving multi-omics integration and uncovering protein-driven intercellular dynamics.

Nature Communications · May 7, 2026Peer-reviewedBioinformatics

Disentangled multimodal evolutionary representations for cross-virus predictive modeling of antigenic change

Zehong Zhang, Yuxi Lin, Siyun Zhong, Peng Zhou, Yixue Li, Fulong Yu

DERIVE predicts antigenic change across viruses using disentangled latent representations of evolutionary history, showing strong transferability to diverse viral families.

bioRxiv · Feb 13, 2026 · PreprintBioinformatics

Dissecting sequence determinants of DNA methylation and in silico perturbation

Fa‐Ming Chen, Qinhao Zhang, Shiwei Zhu, Jinxia Liang, Siyun Zhong, Zehong Zhang, Jianzhong Su, Yangfan Guo, Xiaoying Fan, Yan Zhang, Fulong Yu

This paper introduces MethylAI, a deep learning framework that predicts DNA methylation states from genomic sequence and identifies sequence determinants of methylation through in silico perturbation.

bioRxiv · Nov 20, 2025 · PreprintGenomics