Zehong Zhang

The paper maps the spatial and structural proteome architecture of HEK293 cells using subcellular fractionation and cross-linking mass spectrometry, identifying residue-level protein interactions and expanding the human cell interactome.

DERIVE predicts antigenic change across viruses using disentangled latent representations of evolutionary history, showing strong transferability to diverse viral families.

This paper introduces MethylAI, a deep learning framework that predicts DNA methylation states from genomic sequence and identifies sequence determinants of methylation through in silico perturbation.

The paper develops recombinant protein standards and a search engine for XL-MS, showing Scout outperforms existing tools in speed, sensitivity, and false-discovery rate control.