TBK1 eliminates aggregation-prone monomeric TDP-43 through the IFNβ-immunoproteasome pathway
Shohei Sakai, Kotaro Oiwa, Yohei Iguchi, Seiji Watanabe, Okiru Komine, Mai Horiuchi, Masahisa Katsuno, Koji Yamanaka
This study identifies the TBK1-IFNβ-immunoproteasome pathway as a mechanism by which TBK1 reduces TDP-43 aggregation in ALS and FTD.
bioRxiv · Apr 29, 2025 · PreprintNeuroscience