Masahisa Katsuno

This study identifies tegmental atrophy in iRBD using VBM and a novel brainstem atlas, linking atrophy in specific nuclei to autonomic dysfunction.

The paper uses human iPSC-derived motor neurons to study SBMA, identifying neuropeptides as therapeutic targets.

This study identifies dysregulated synaptic gene expression in oligodendrocytes of SBMA mice, highlighting early cell-to-cell communication changes as a potential therapeutic target.

This study identifies the Aβ-HMGB1 complex as a pathogenic factor in advanced Alzheimer's disease, showing it causes neuronal damage and that targeting HMGB1 improves symptoms in mouse models.

This study identifies the TBK1-IFNβ-immunoproteasome pathway as a mechanism by which TBK1 reduces TDP-43 aggregation in ALS and FTD.

This study shows that psychosocial stress alters feeding behavior patterns in mice through disruptions in the mesolimbic dopamine system, suggesting these patterns could serve as biomarkers for stress and neuropsychiatric disorders.

The paper identifies dysregulated expanded endocannabinoid system metabolites in ALS and shows FAAH inhibition improves motor neuron degeneration in models.

The paper identifies a GGC repeat expansion in the NOTCH2NLC gene using long-read sequencing, linking it to neuronal intranuclear inclusion disease in both familial and sporadic cases.