A novel SERPINE1-FOSB fusion gene in a case of pseudomyogenic hemangioendothelioma results in activation of intact FOSB and the PI3K-AKT-mTOR signaling pathway and responsiveness to sirolimus
Jun Ren, Xiaohui Wang, Yulin Zhou, Xin Yue, Shouhui Chen, Xin Ding, Shengqiang Zeng, Xiaoyong Jiang, Xiaokun Liu, Qiwei Guo
This study reports a novel SERPINE1-FOSB fusion gene in pseudomyogenic hemangioendothelioma that activates the PI3K-AKT-mTOR pathway and responds to sirolimus treatment.
The Journal of Dermatology · Sep 27, 2021Peer-reviewedGenetics