T cell self-reactivity during thymic development dictates the timing of positive selection
Lydia Kay Lutes, Zoë Steier, Laura Lynn McIntyre, Shraddha Pandey, James Kaminski, Ashley R. Hoover, Silvia Ariotti, Aaron Streets, Nir Yosef, Ellen A. Robey
This study shows that low self-reactive thymocytes have shorter TCR signals, delayed positive selection, and retain preselection gene expression signatures, suggesting ion channels modulate TCR sensitivity during development.
eLife · Apr 22, 2021Peer-reviewedDevelopmental Biology