Author

Laura Lynn McIntyre

University of California SystemORCID 0000-0001-7820-4431Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Aaron StreetsiD· 2 shared Ellen A. RobeyiD· 2 shared Lydia Kay LutesiD· 2 shared Nir YosefiD· 2 shared Zoë SteieriD· 2 shared Ashley R. HooveriD· 1 shared Can ErgeniD· 1 shared Dominik A. AylardiD· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

Aaron StreetsORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintJul 12, 2021

Single-cell multi-omic analysis of thymocyte development reveals drivers of CD4/CD8 lineage commitment

Zoë Steier, Dominik A. Aylard, Laura Lynn McIntyre…·Aaron Streets

This study uses CITE-seq to analyze thymocyte development and identifies TCR signaling waves and the TCR/calcineurin/NFAT/GATA3 axis as drivers of CD4/CD8 lineage commitment.

3 citations

mouseCITE-seq

𝕏 PostBluesky

Developmental BiologyeLifePeer-reviewedApr 22, 2021

T cell self-reactivity during thymic development dictates the timing of positive selection

Lydia Kay Lutes, Zoë Steier, Laura Lynn McIntyre…·Ellen A. Robey

This study shows that low self-reactive thymocytes have shorter TCR signals, delayed positive selection, and retain preselection gene expression signatures, suggesting ion channels modulate TCR sensitivity during development.

26 citations

mouseexperimental assay

𝕏 PostBluesky