Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition
Akanksha Swarup, Ryan A Kuhs, Vanessa U Hardman, Kennedy L Howard, Shradha Subbaraman, Timothy A. Bolger
The paper shows that DDX3X mutations in medulloblastoma disrupt translational responses to TORC1 inhibition, selectively upregulating unstructured mRNAs and promoting tumor growth.
Journal of Biological Chemistry · Sep 18, 2026Peer-reviewedMolecular Biology