Molecular BiologyJournal of Biological ChemistryPeer-reviewed
Medulloblastoma-associated mutations in the RNA helicase DDX3X/DED1 cause defects in the translational response to TORC1 inhibition
Akanksha Swarup, Ryan A Kuhs, Vanessa U Hardman…·Timothy A. Bolger
The paper shows that DDX3X mutations in medulloblastoma disrupt translational responses to TORC1 inhibition, selectively upregulating unstructured mRNAs and promoting tumor growth.
DOI 10.1016/j.jbc.2026.113580