Consequences of alanine-126 mutations in helix-3 on structure and functions of Rad6 E2 ubiquitin-conjugating enzymes
Prakash Shukla, Dhiraj Prasad Sinha, Andrew M. Leng, Jesse E. Bissell, Shravya Thatipamula, Rajarshi Ganguly, Kaitlin S. Radmall, Jack J. Skalicky, Dennis C. Shrieve, Mahesh B. Chandrasekharan
This study investigates how mutations at alanine-126 in helix-3 of Rad6 affect its ubiquitination activity and structural stability in yeast and human homologs.
Journal of Biological Chemistry · Sep 23, 2022Peer-reviewedMolecular Biology