Mahesh B. Chandrasekharan

This study identifies circPCMTD1 as a circular RNA that promotes leukemic cell proliferation by enhancing DNA damage response tolerance through a novel peptide product.

The paper identifies Jade1 as a cofactor of Oct4 that selectively interacts with specific DNA configurations to enhance histone acetylation and transcriptional regulation.

The paper demonstrates that deleting deubiquitinases in yeast enables studying ubiquitination dynamics of target proteins like histone H2B and PCNA in vivo.

This study identifies a redox-sensitive cysteine residue in Oct4 that regulates reprogramming and differentiation by affecting DNA binding and ubiquitylation.

This study investigates how mutations at alanine-126 in helix-3 of Rad6 affect its ubiquitination activity and structural stability in yeast and human homologs.

This study shows that Oct1 works with Smad factors to activate mesodermal genes during differentiation, improving understanding of lineage specification.

The paper investigates how FACT activity and H3-K56 acetylation influence chromatin architecture and transcription in yeast, finding they optimize transcription frequency and restore chromatin integrity independently of ongoing transcription.