Cancer BiologyCell Death DiscoveryPeer-reviewed
New Δ246p53 isoform responds to DNA damage to enhance p53 family functions in cellular senescence
Shrutee N. Parkar, Ana Catarina Ramalho, Maria José López-Iniesta…·Marco M. Candeias
The paper identifies a new p53 isoform, Δ246p53, which is induced by DNA damage, promotes senescence, and modulates p21 expression through interactions with FLp53 and ΔNp63.
3 citations