Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbations
Tulsi Patel, Troy Carnwath, Xue Wang, Mariet Allen, Sarah Lincoln, Laura J. Lewis‐Tuffin, Zachary Quicksall, Shu Lin, Frederick Q Tutor‐New, Charlotte C.G. Ho, Yuhao Min, Kimberly G. Malphrus, Thuy Nguyen, Elizabeth Martin, César A. Garcia, , Nilüfer Ertekin‐Taner
The paper characterizes human microglia transcriptomes and identifies gene expression signatures linked to age, sex, and APOE-ε4, revealing immunometabolic pathway perturbations in neurodegeneration.
bioRxiv · May 13, 2021 · PreprintGenetics