Author

Kimberly G. Malphrus

Mayo Clinic in Florida

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 5 Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:gene regulatory network inference· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

Mariet AlleniD· 5 shared Nilüfer Ertekin‐TaneriD· 5 shared Thuy NguyeniD· 5 shared Xue WangiD· 5 shared Dennis W. DicksoniD· 4 shared Joseph S. ReddyiD· 4 shared Minerva M. CarrasquilloiD· 4 shared Zachary QuicksalliD· 4 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersNeuroscience

Mariet AllenORCID

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Author profile →

5 papers

Recent·Most cited

Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's Disease related proteins

Stephanie R. Oatman, Joseph S. Reddy, Zachary Quicksall, Minerva M. Carrasquillo, Xue Wang, Chia‐Chen Liu, Yu Yamazaki, Thuy Nguyen, Kimberly G. Malphrus, Michael G. Heckman, Kristi Biswas, Kwangsik T. Nho, Matthew Baker, Yuka A. Martens, Na Zhao, , Nilüfer Ertekin‐Taner

This study performs a genome-wide association study of brain biochemical phenotypes in Alzheimer's patients, identifying novel genetic loci and highlighting distinct genetic architectures for AD-related proteins.

Molecular Neurodegeneration · Jan 6, 2023Peer-reviewedGenetics

Single Nuclei Transcriptome Reveals Perturbed Brain Vascular Molecules in Alzheimer's Disease

Özkan İş, Xue Wang, Tulsi Patel, Zachary Quicksall, Michael G. Heckman, Launia J. White, Laura J. Lewis‐Tuffin, Kaancan Deniz, Frederick Q Tutor‐New, Troy Carnwath, Yuhao Min, Stephanie R. Oatman, Joseph S. Reddy, Minerva M. Carrasquillo, Thuy Nguyen, , Nilüfer Ertekin‐Taner

The paper uses single nucleus RNA sequencing to analyze brain vascular cells in Alzheimer's disease, identifying molecular changes and interactions between vascular and astrocytic cells at the blood-brain barrier.

bioRxiv · Dec 28, 2021 · PreprintNeuroscience

Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbations

Tulsi Patel, Troy Carnwath, Xue Wang, Mariet Allen, Sarah Lincoln, Laura J. Lewis‐Tuffin, Zachary Quicksall, Shu Lin, Frederick Q Tutor‐New, Charlotte C.G. Ho, Yuhao Min, Kimberly G. Malphrus, Thuy Nguyen, Elizabeth Martin, César A. Garcia, , Nilüfer Ertekin‐Taner

The paper characterizes human microglia transcriptomes and identifies gene expression signatures linked to age, sex, and APOE-ε4, revealing immunometabolic pathway perturbations in neurodegeneration.

bioRxiv · May 13, 2021 · PreprintGenetics

Conserved Architecture of Brain Transcriptome Changes between Alzheimer's Disease and Progressive Supranuclear Palsy in Pathologically Affected and Unaffected Regions

Xue Wang, Mariet Allen, Joseph S. Reddy, Minerva M. Carrasquillo, Yan W. Asmann, Cory C. Funk, Thuy Nguyen, Kimberly G. Malphrus, Steven G. Younkin, Dennis W. Dickson, Nathan D. Price, Todd Eliot Golde, Nilüfer Ertekin‐Taner

bioRxiv · Jan 18, 2021 · PreprintNeuroscience

Deciphering cellular transcriptional alterations in Alzheimer's disease brains

Xue Wang, Mariet Allen, Shaoyu Li, Zachary Quicksall, Tulsi Patel, Troy Carnwath, Joseph S. Reddy, Minerva M. Carrasquillo, Sarah Lincoln, Thuy Nguyen, Kimberly G. Malphrus, Dennis W. Dickson, Julia E. Crook, Yan W. Asmann, Nilüfer Ertekin‐Taner

The paper identifies cell-intrinsic differentially expressed genes in Alzheimer's disease by analyzing bulk-RNAseq data and comparing results to single nucleus RNAseq.

Molecular Neurodegeneration · Jul 13, 2020Peer-reviewedNeuroscience