Troy Carnwath

This study identifies CPI203, a BET inhibitor, as a compound that consistently down-regulates DNA synthesis genes across multiple glioblastoma lines.

The paper uses single nucleus RNA sequencing to analyze brain vascular cells in Alzheimer's disease, identifying molecular changes and interactions between vascular and astrocytic cells at the blood-brain barrier.

The paper characterizes human microglia transcriptomes and identifies gene expression signatures linked to age, sex, and APOE-ε4, revealing immunometabolic pathway perturbations in neurodegeneration.

The paper identifies SERPINA5 as a novel tau binding partner in Alzheimer's disease by analyzing hippocampal gene expression and neurofibrillary tangles.

The paper identifies cell-intrinsic differentially expressed genes in Alzheimer's disease by analyzing bulk-RNAseq data and comparing results to single nucleus RNAseq.