Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer
Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji
The paper identifies key chemical features of inhibitors binding to the human mitochondrial pyruvate carrier hetero-dimer and discovers new inhibitors with higher potency than existing ones.
Molecular Metabolism · Mar 9, 2022Peer-reviewedMolecular Biology