Vasiliki Mavridou

Molecular mechanism of action of a blood brain barrier shuttle antibody

This study determines the cryo-EM structure of a brain shuttle antibody bound to the transferrin receptor and shows how its binding features affect avidity, pH sensitivity, and brain delivery.

A robust platform for recombinant production of animal venom toxin modulators of ion channels

This paper develops a method to produce animal venom toxins using recombinant Fc-fusion proteins, achieving high yields and functionality for various toxin types.

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

The paper identifies key chemical features of inhibitors binding to the human mitochondrial pyruvate carrier hetero-dimer and discovers new inhibitors with higher potency than existing ones.