Pharmacological targeting of EED is an effective therapeutic strategy in cellular models of incurable neuroendocrine prostate cancer
Kayleigh J. A. Orchard, George Bryant, Maryam Latarani, Isabel R Misir, Satyanarayana M Yerra, Christos N. Velanis, Marta Banchi, Irene Fischetti, Steven L Turnball, Mark Eccleston, Theresa Kathleen Kelly, Edwina Burke, Zoe R. Maylin, Guido Bocci, Jonathan Shamash, , Francesco Crea
This study compares tazemetostat and ORIC-944 in NEPC and PRAD cells, finding ORIC-944 more effective in inducing apoptosis and growth inhibition.
bioRxiv · Feb 25, 2026 · PreprintCancer Biology