Author

Francesco Crea

The Open UniversityORCID 0000-0002-4903-2973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Yuzhuo Z. WangiD· 3 shared Dong LiniD· 2 shared Elena JachettiiD· 2 shared Irene FischettiiD· 2 shared Mark EcclestoniD· 2 shared Maryam LataraniiD· 2 shared Abhijit ParoliaiD· 1 shared Adam R. BrentnalliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Yuzhuo Z. WangORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Pharmacological targeting of EED is an effective therapeutic strategy in cellular models of incurable neuroendocrine prostate cancer

Kayleigh J. A. Orchard, George Bryant, Maryam Latarani, Isabel R Misir, Satyanarayana M Yerra, Christos N. Velanis, Marta Banchi, Irene Fischetti, Steven L Turnball, Mark Eccleston, Theresa Kathleen Kelly, Edwina Burke, Zoe R. Maylin, Guido Bocci, Jonathan Shamash, , Francesco Crea

This study compares tazemetostat and ORIC-944 in NEPC and PRAD cells, finding ORIC-944 more effective in inducing apoptosis and growth inhibition.

bioRxiv · Feb 25, 2026 · PreprintCancer Biology

Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation

Yu Wang, Hui Xue, Xiaohui Zhu, Dong Lin, Zheng Chen, Xin Dong, Junru Chen, Mingchen Shi, Yuchao Ni, Jonathan Cao, Rebecca Wu, Connie Kang, Xinyao Pang, Francesco Crea, Yen‐Yi Lin, , Yuzhuo Z. Wang

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.

Advanced Science · Mar 17, 2025Peer-reviewedCancer Biology

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive variant prostate cancer

Maryam Latarani, Perla Pucci, Mark Eccleston, Massimiliano Manzo, Priyadarsini Gangadharannambiar, Irene Fischetti, Ilaria Alborelli, Vera Mongiardini, Namra Mahmood, Mario Paolo Colombo, Benedetto Grimaldi, Sushilaben H. Rigas, Shusuke Akamatsu, Cheryl A. Hawkes, Yuzhuo Z. Wang, , Francesco Crea

This study shows that EZH2 inhibition enhances platinum chemotherapy effectiveness in aggressive variant prostate cancer by reducing H3K27me3 and modulating DNA repair and apoptosis pathways.

Epigenomics · Jan 29, 2025Peer-reviewedPharmacology & Toxicology