Dong Lin

This study uses longitudinal scRNA-seq to track neuroendocrine transdifferentiation in a prostate cancer model, identifying transcriptional changes and key regulators during treatment-induced NEPC progression.

This study compares tazemetostat and ORIC-944 in NEPC and PRAD cells, finding ORIC-944 more effective in inducing apoptosis and growth inhibition.

This study uses longitudinal single-cell RNA sequencing to identify RUNX1T1 as a key regulator in the transition and maintenance of treatment-induced neuroendocrine prostate cancer.

This study identifies lineage-specific transcription factor profiles in prostate cancer progression, revealing dynamic shifts during NE transdifferentiation and proposing a three-phase model.