Author

Irene Fischetti

Fondazione IRCCS Istituto Nazionale dei TumoriORCID 0009-0002-3946-6388Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Elena JachettiiD· 2 shared Francesco CreaiD· 2 shared Mark EcclestoniD· 2 shared Maryam LataraniiD· 2 shared Yuzhuo Z. WangiD· 2 shared Adam R. BrentnalliD· 1 shared Benedetto GrimaldiiD· 1 shared Cheryl A. HawkesiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

Elena JachettiORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 25, 2026

Pharmacological targeting of EED is an effective therapeutic strategy in cellular models of incurable neuroendocrine prostate cancer

Kayleigh J. A. Orchard, George Bryant, Maryam Latarani…·Francesco Crea

This study compares tazemetostat and ORIC-944 in NEPC and PRAD cells, finding ORIC-944 more effective in inducing apoptosis and growth inhibition.

DOI 10.64898/2026.02.24.707688

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologyEpigenomicsPeer-reviewedJan 29, 2025

EZH2 inhibition enhances the activity of platinum chemotherapy in aggressive variant prostate cancer

Maryam Latarani, Perla Pucci, Mark Eccleston…·Francesco Crea

This study shows that EZH2 inhibition enhances platinum chemotherapy effectiveness in aggressive variant prostate cancer by reducing H3K27me3 and modulating DNA repair and apoptosis pathways.

6 citations

humanbulk RNA-seq

𝕏 PostBluesky