Theresa Kathleen Kelly

The paper uses ATAC-Seq to study chromatin accessibility in neutrophils stimulated with inflammatory factors, finding stimulus-specific programs linked to sepsis transcriptional states.

The paper uses long-read sequencing to analyze cfDNA fragmentation patterns in cancer patients, identifying hypofragmentation and hyperfragmentation linked to elevated cfDNA levels.

This study compares tazemetostat and ORIC-944 in NEPC and PRAD cells, finding ORIC-944 more effective in inducing apoptosis and growth inhibition.

This study compares chromatin accessibility changes during NET formation in whole blood versus isolated neutrophils, finding that whole blood responses show stronger immune pathway activation.

The paper examines chromatin dynamics in primary human neutrophils during PMA-induced NETosis, identifying early chromatin changes linked to NOX-dependent NET formation.

This paper introduces a novel ex-vivo whole blood model for inducing NETosis using physiological triggers, showing that three factors are required and responses vary between donors.