Cryo-EM structures of the MnmE-MnmG complex reveal large conformational changes and provide new insights into the mechanism of tRNA modification
Laila Maes, Israel Mares‐Mejía, Ella Martin, David Bickel, Siemen Claeys, Wim Vranken, Marcus Fislage, Christian Galicia, Wim Versées
The paper reports cryo-EM structures of the MnmE-MnmG complex in different oligomeric states, revealing conformational changes and a mechanism for substrate and cofactor transfer during tRNA modification.
Nucleic Acids Research · Aug 7, 2025Peer-reviewedBiochemistry