David Bickel

The paper reports cryo-EM structures of the MnmE-MnmG complex in different oligomeric states, revealing conformational changes and a mechanism for substrate and cofactor transfer during tRNA modification.

The paper identifies non-charged analogs of the inhibitor 7.44 that show improved antiproliferative effects against RUNX1-ETO positive cells.

The paper defines six low energy conformational states for amino acid residues using solution NMR data and introduces a variability parameter to assess conformational state transitions.

This study uses molecular dynamics simulations to analyze how phosphorylations affect protein backbone dynamics and conformational preferences, validated against NMR data.