Israel Mares‐Mejía

The paper shows that LiTat 1.3, a key VSG for diagnosing T. b. gambiense, forms homotrimers in solution, not homodimers, using structural and biophysical methods.

This study identifies histamine as a novel activator of complement C3, forming C3h which accelerates complement activation and inflammation.

The paper reports cryo-EM structures of the MnmE-MnmG complex in different oligomeric states, revealing conformational changes and a mechanism for substrate and cofactor transfer during tRNA modification.