Anti-Parkinsonian Drugs Rescue Locomotor Deficits in JIP3 Knockout Zebrafish: Implications for Treating Patients with MAPK8IP3-related Neurodevelopmental Disorders
Aleksandra Foksinska, Jaclyn Paige Souder, Gabrielle Smith, Kinnsley Travis, Sienna Rucka, Addie Allred, Rebeca Bender, Jackie Brunson, Avary Lanier, Amber Glaze, Andrew B. Crouse, Matthew Might, Camerron M. Crowder
The paper identifies amantadine and levodopa as potential therapies for JIP3-related neurodevelopmental disorders using zebrafish models and AI-assisted drug screening.
bioRxiv · Feb 2, 2025 · PreprintNeuroscience