Vitamin D3 ameliorates R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids
Sribalasubashini Muralimanoharan, Ana Corachán, Azad Khosh, Sierra Hathaway, Natalia Garcia, S. Karthigayan, Claire M. Schenken, Nicholas M. Stansbury, Robert Spencer Schenken, María Victoria Bariani, Qiwei Yang, Eloise V. Dray, Mazhar Adli, Hortensia Ferrero, Ayman Al-Hendy, Thomas G. Boyer
This study shows that vitamin D3 reduces R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids, leading to growth inhibition in xenograft models.
Scientific Reports · Jul 6, 2026Peer-reviewedMolecular Biology