Mazhar Adli

ExPert infers causal perturbations from cell states by learning prototypes across 12 contexts, achieving high recall with low compute and validating findings in disease models.

The paper maps major histone modifications in a reef-building coral to understand chromatin regulation of gene expression and identifies distinct epigenetic states.

This study demonstrates that AAV-DJ efficiently and safely transduces human ovarian cells, enabling targeted gene modulation with significant knockdown of AMHR2 and TGF{beta}1.

This study shows that vitamin D3 reduces R-loop-induced replication stress and chromosomal instability in MED12-mutant uterine fibroids, leading to growth inhibition in xenograft models.

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

This study identifies ISL2 as an epigenetically silenced tumor suppressor in pancreatic cancer that regulates metabolism and presents therapeutic vulnerabilities.