An oral fentanyl self-administration model reveals dissociable escalation and relapse phenotypes in outbred vs inbred mice
Todd R Appleby, Lukas K. MacMillen, Erica L. Sanchez, Sierra Schleufer, John F. Neumaier, Sam A. Golden, Kevin R. Coffey
This paper develops an oral fentanyl self-administration model in mice to study escalation and relapse phenotypes, finding genetic background influences on these behaviors.
bioRxiv · Aug 4, 2026 · PreprintNeuroscience