TREM2-dependent senescent microglia conserved in aging and Alzheimer's disease
Noa Rachmian, Silvia Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, TM. Salame, Javier María Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwartz
The paper identifies TREM2-dependent senescent microglia in aging and Alzheimer's disease, showing that TREM2 inhibition reduces their abundance and improves cognitive deficits.
bioRxiv · Mar 20, 2023 · PreprintNeuroscience