Valery Krizhanovsky

Systemic administration of PD-L1 blocking antibodies leads to removal of senescent microglia

The paper shows that systemic PD-L1 blockade removes senescent microglia in mice, reducing neuroinflammation and suggesting a therapeutic role in Alzheimer's disease.

Cell surface ATP6V1B2 marks a subset of persistent senescent cells with increased resistance to apoptosis

The paper identifies a subset of senescent cells marked by surface ATP6V1B2 that exhibit increased resistance to apoptosis and are associated with DNA repair.

Single-cell quantification of senescence burden reveals cell type-specific ageing dynamics across organs

This study quantifies senescence burden at the single-cell level across tissues in mice and human PBMCs, revealing tissue-specific ageing dynamics and senescence marker heterogeneity.

TREM2-dependent senescent microglia conserved in aging and Alzheimer's disease

The paper identifies TREM2-dependent senescent microglia in aging and Alzheimer's disease, showing that TREM2 inhibition reduces their abundance and improves cognitive deficits.

Senescent cells and the dynamics of aging

The paper combines theory and experiments in mice to show that senescent cells have a rapid turnover that saturates with age, leading to persistent differences in cell accumulation and explaining demographic mortality laws.