Dunya Edilbi

The paper develops a pipeline to identify condition-specific enzymes in yeast, revealing a function for the uncharacterized Bdh2 alcohol dehydrogenase.

The paper introduces an AID library for on-demand protein depletion in yeast, enabling systematic study of protein function and uncovering new roles in cell cycle and mitochondrial processes.

The paper uses a bi-genomic split-GFP assay to identify mitochondrial matrix and inner membrane proteins, revealing 50 previously unvisualized proteins and characterizing dually localized proteins.

The paper identifies TREM2-dependent senescent microglia in aging and Alzheimer's disease, showing that TREM2 inhibition reduces their abundance and improves cognitive deficits.