Multi-modal single-cell and whole-genome sequencing of minute, frozen specimens to propel clinical applications
Yiping Wang, Joy Linyue Fan, Johannes C. Melms, Amit Dipak Amin, Yohanna Georgis, Patricia Ho, Somnath Tagore, Gabriel Abril-Rodríguez, Jana Biermann, Matan Hofree, Lindsay Caprio, Simon Berhe, Shaheer A. Khan, Brian S. Henick, Antoni Ribas, , Benjamin Izar
This study develops a method for single-cell and whole-genome sequencing of frozen clinical specimens, demonstrating its utility in analyzing tumor evolution and rare disease biospecimens.
bioRxiv · Feb 13, 2022 · PreprintGenomics