Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: A revision of the prohypertrophic signalling network concept
Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch, Sven Schmidt, Christian Merle, Wiltrud Richter
This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.
bioRxiv · Mar 12, 2024Cell Biology