Author

Solvig Diederichs

University Hospital HeidelbergORCID 0000-0002-2527-9517Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Wiltrud RichteriD· 3 shared Helen F. DietmariD· 2 shared Sven Christian SchmidtiD· 2 shared Andrea VortkampiD· 1 shared Attila AszódiiD· 1 shared Christian MerleiD· 1 shared Felicia A. M. KlampfleuthneriD· 1 shared Matthias GerstneriD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCell Biology

Wiltrud RichterORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintSep 2, 2025

Dichotomous SMAD2/3 regulation and selective anti-hypertrophic activity of heparin during in vitro chondrogenesis of mesenchymal stromal cells

Sven Christian Schmidt, Safak Chasan, Helen F. Dietmar…·Solvig Diederichs

This study shows that heparin promotes endochondral differentiation of MSCs in vitro but chondral development in vivo, with selective anti-hypertrophic effects through SMAD2/3 regulation.

DOI 10.1101/2025.09.02.673657

humanproteomics

𝕏 PostBluesky

Cell BiologyMatrix BiologyPeer-reviewedMay 14, 2025

Load activated FGFR and beta1 integrins target distinct chondrocyte mechano-response genes

Helen F. Dietmar, Pia A. Weidmann, Paolo Alberton…·Solvig Diederichs

This study identifies distinct mechano-response genes regulated by load-activated FGFR and beta1 integrins in chondrocytes, showing they control different subsets of genes.

5 citations

mousehuman

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Cell BiologyStem Cell Research & TherapyPeer-reviewedApr 5, 2024

Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: A revision of the prohypertrophic signalling network concept

Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch…·Wiltrud Richter

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.

6 citations

humanbulk RNA-seq

𝕏 PostBluesky