Computational Assessment of Circularization Impact on Saxitoxin G-quadruplex Aptamer Performance
Siyi Gao, Bowen Deng, Dingyuan Cheng, Rong Zhou, Yulong Wu, Yuanyu Jia, Boyi Xiao, Haowen Yu, Zhenxia Ma, Yun Gao, Tao Li, Genkun Liu, Yinuo Zhang, Jun Cheng, Hu Zhu, , Mingjuan Sun
The paper develops a computational method to guide the cyclization of saxitoxin aptamers, showing that circular aptamers have higher affinity and improved survival in mice.
bioRxiv · May 5, 2025 · PreprintBiochemistry