Hu Zhu

Cost-saving, trading, and internalization of externality: three economic strategies underlying amino acid archetypes of human metabolic enzymes

The paper identifies three economic strategies underlying amino acid composition patterns in human metabolic enzymes, revealing a multi-layered proteome-level economic system in multicellular organisms.

Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity

The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.

Computational Assessment of Circularization Impact on Saxitoxin G-quadruplex Aptamer Performance

The paper develops a computational method to guide the cyclization of saxitoxin aptamers, showing that circular aptamers have higher affinity and improved survival in mice.

Cell-type selective deletion of RSK2 reveals insights into altered signaling in Coffin-Lowry Syndrome

This study shows that deleting RSK2 in mice increases psychostimulant responses and 5-HT2A receptor signaling, linking RSK2 dysfunction to schizophrenia-like behaviors in Coffin-Lowry Syndrome.