Author

Jun Cheng

National Institutes of HealthORCID 0000-0002-7281-8683Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Jun Cheng1 paper · Center for Excellence in Molecular Cell Science

Biology Disciplines

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Biochemistry· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Astrid BrulliD· 1 shared Berit Lubben· 1 shared Bowen Deng· 1 shared Boyi XiaoiD· 1 shared Carsten G. BönnemanniD· 1 shared Dingyuan Cheng· 1 shared Fady GuirguisiD· 1 shared Genkun Liu· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetics

Astrid BrullORCID

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2 papers

Recent·Most cited

Computational Assessment of Circularization Impact on Saxitoxin G-quadruplex Aptamer Performance

Siyi Gao, Bowen Deng, Dingyuan Cheng, Rong Zhou, Yulong Wu, Yuanyu Jia, Boyi Xiao, Haowen Yu, Zhenxia Ma, Yun Gao, Tao Li, Genkun Liu, Yinuo Zhang, Jun Cheng, Hu Zhu, , Mingjuan Sun

The paper develops a computational method to guide the cyclization of saxitoxin aptamers, showing that circular aptamers have higher affinity and improved survival in mice.

bioRxiv · May 5, 2025 · PreprintBiochemistry

A humanized knock-in Col6a1 mouse recapitulates a deep-intronic splice-activating variant

Véronique Bolduc, Fady Guirguis, Berit Lubben, Lindsey Trank, Sarah Silverstein, Astrid Brull, Matthew Nalls, Jun Cheng, Lisa J Garrett, Carsten G. Bönnemann

The paper creates a humanized knock-in mouse model with a deep-intronic splice-activating variant to test antisense therapeutics for Collagen VI-related muscular dystrophies.

bioRxiv · Mar 21, 2024 · PreprintGenetics