URA6 mutations provide an alternative mechanism for 5-FOA resistance in Saccharomyces cerevisiae
Joseph O. Armstrong, Pengyao Jiang, Skyler Tsai, Megan My-Ngan Phan, Amy A. Caudy, Kelley Harris, Maitreya J. Dunham
The paper identifies URA6 mutations that confer 5-FOA resistance in yeast, showing cross-resistance to other fluorinated compounds and revealing a reduction in uridylate kinase activity.
bioRxiv · Jun 3, 2024 · PreprintGenetics