Infection with Mycobacterium tuberculosis orchestrates the PRMT5-dependent methylation of NCOA4 to govern host ferroptosis
Smriti Sundar, Raju S Rajmani, Kithiganahalli Narayanaswamy Balaji
This study identifies PRMT5-dependent methylation of NCOA4 as a mechanism by which Mtb induces ferroptosis in host macrophages to enhance its survival and dissemination.
bioRxiv · Oct 23, 2025 · PreprintMicrobiology